Medical Products Supplies Companies

Robert-Rössle-Str. 10, 13125 Berlin
Germany
Telephone +49 30 94892130
Fax +49 30 9494509
info@biotez.de
http://www.biotez.de

Product Categories

Product categories

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.01 Immuno assay testing

Immuno assay testing

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.02 Diagnostic rapid tests

Diagnostic rapid tests

03 Diagnostic Tests
03.05 Infectious immunology testing
03.05.01 Bacteriology testing

Bacteriology testing

03 Diagnostic Tests
03.07 Other diagnostics

Other diagnostics

Our products

Product category: Immuno assay testing, Diagnostic rapid tests, Bacteriology testing, Other diagnostics
The TAPAS labelling Kit as alternative to the classical Biotin-Streptavidin system
The TA-PAS System is a fast two component protein-ligand interaction system. One component is the small synthetic label called “TA-Label” (<1000 Da). The second component is the “PAS-Antibody” which binds the “TA-Label” with high specificity and efficiency.

The TA-PAS System supports a large number of applications including immobilization, enrichment or detection of antibodies, other proteins, primers and other nucleic acids. The TA-PAS System is a simple yet elegant system to link TA labelled molecules in assays by exploiting the high affinity to PAS capture antibody.

Fast binding universal detection system, e.g. lateral flow assay
ELISA, it can be used as detection or coating component
Immunohistochemistry (IHC)
Western-, Southern- und Northern Blot
Immunoaffinity chromatography
Cell surface labelling etc.

Alternative to Biotin-Streptavidin or in combination with Biotin-Streptavidin
TA-PAS with double labelled molecules like primers, antibodies, Proteins
Immunoprecipitation: Immobilization of target molecules from cell culture or other biological samples
Target molecule enrichment
Application Example: Lateral Flow Test
Application of TA-PAS system in lateral flow in combination with a double labelling strategy
(antibody conjugated with Gold nanoparticles and TA-Label)
for immobilization at control line and streptavidin/biotin system for test line.

Advantages of the TA-PAS System compared with a clasical Biotin-Streptavidin System

The TA-PAS system allows a flexible, simple use in many applications
Improvement of signal-noise ratio
High affinity binding between TA-Label and PAS-Antibody (capture antibody)
Fast Binding
Low cross-reactivity
Low non-specific binding
TA-PAS interaction is artificial and not present in nature
No problems with samples or proteins with biotin (e.g. Carboxylases, Histones)
pH-stable
Long shelf life time
Reproducible results

No problems with PAS coating followed by blocking with serum
No problems with double labelling strategies for lateral flow test
Application Example: Immobilisation of TA-labelled Molecules for Target molecule enrichment
The TA-PAS labelling kit allows antibodies, proteins, primer etc. to be covalently labelled with the TA-Label quickly and easily. The pre-activated TA-Label is designated for the coupling reaction with target molecules through the reaction with primary amino groups.

BioTeZ TA-PAS labelling kit includes the PAS-Antibody (capture antibody), all necessary reagents to label the target molecule with the TA-Labels and a clean-up column for purifying the coupling product (separation of unbound labels). Generally, the TA-Label is fully compatible with other labels and should work well.

Product category: Immuno assay testing, Diagnostic rapid tests, Other diagnostics
The Polystreptavidin R Surface Functionalization Kit
The Polystreptavidin R Surface Functionalization Kit combines the excellent binding capacity with a high chemo and thermo stability.Additional pre-coating serves to improve the outcome and especially for very inert surfaces to ensure high quality coatings with Polystreptavidin R.

Polystreptavidin R provides product consistency and helps to reduce variability in diagnostic assays. Test it; make the comparison of BioTeZ Polystreptavidin R Coating Kit and surface activated beads or other surface activations. Typical applications where Polystreptavidin R is used: IVD assays, isolation and purification of biotinylated molecules, ligand coupling.

The BioTeZ Polystreptavidin R Coating Kit (Product Code: BTCK-MC) is useful for adsorptive coatings on microplates, beads, membranes etc. made of metal, nitrocellulose, ceramic, silicon, glass or plastics like Polystyrene, Polyethylene, Polypropylene, Polycarbonate, Poly(methyl methacrylate) PMMA or Polyamides with “Maximum Biotin Binding Capacity”.

Product category: Immuno assay testing, Other diagnostics
BioTeZ offers a wide range of products and services in the field of Human Proteases Research, such as human MMPs, human ADAMTSor human HtrAs
BioTeZ offers a wide range of products and services in the field of Human Proteases Research, such as human MMPs (Matrix Metalloproteinases), human ADAMTS (A Disintegrin And Metalloprotease with Thrombospondin motifs) or human HtrAs (High temperature requirement factor A) to support drug development, especially therapeutic or neutralizing antibodies, antibody drug conjugates (ADC) or target screening and diagnostics, e.g. for preclinical phases, trials, pharmacokinetic (pk) and pharmacodynamic (pd) studies.

Proteases have relevance in the control of multiple biological processes in all living organisms. They regulate the activities of many proteins, modulate protein-protein interactions, create new bioactive molecules, contribute to the processing of cellular information and generate, transduce and amplify molecular signals. As a direct result of these multiple actions, proteases influence DNA replication and transcription, cell proliferation and differentiation, tissue morphogenesis and remodelling, heat shock and unfolded protein responses, angiogenesis, neurogenesis, ovulation, fertilization, wound repair, stem cell mobilization, haemostasis, blood coagulation, inflammation, immunity, autophagy, senescence, necrosis and apoptosis. Consistent with these essential roles of proteases in cell behaviour, survival and death of all organisms, alterations in proteolytic systems underlie multiple pathological conditions such as cancer, neurodegenerative disorders, inflammatory and cardiovascular diseases.
Our high quality proteins are produced in bacteria and insect cells (Baculovirus expression system) or are isolated from biological fluids.

Test kits, components and services for sensitive determination of protease concentration and protease activity fall within the scope of our Human Proteases Research. We combine the best elements of bead and ELISA technologies. This guarantees high sensitivity and specificity for many applications in various volumes and overcomes the problems caused by the interference of other proteins with the same molecular weight or the inhibition of specific protease detection due to the presence of an abundant amount of other proteins.

Product category: Immuno assay testing, Diagnostic rapid tests, Bacteriology testing, Other diagnostics
Autoimmune & Diagnostic ELISA (IVD)
The BioTeZ ELISA kits are CE marked and come in the standard format of 96 analyses. They all use identical general reagents, namely sample buffer, wash buffer, substrate and stop solution. Hence, one and the same sample dilution may be used for multiple assays; e.g. for simultaneous determination of Cardiolipin IgG and IgM. For more Information please contact us are drop by for a chat at the BioTeZ Stand.

Product category: Immuno assay testing, Diagnostic rapid tests, Bacteriology testing, Other diagnostics
ELISA Development as a Service
ELISA Development as s Service:

ELISA is an abbreviation for Enzyme-Linked Immuno Sorbent Assay. It is used to detect the enzyme-controlled reaction between antigen and antibody. This multi-purpose way of testing is, if used properly, a very sensitive verification procedure. Proteins, antibodies, biomarkers, viruses, hormones, toxins and pharmaceuticals can be analyzed and quantified this way.

For several years BioTeZ has distinguished know-how in the field of ELISA development and creates globally-recognized innovations repeatedly, for example the Therapeutic Drug Monitoring / Companion Diagnostic.

Make use of our knowledge in test development of Sandwich ELISAs, Indirect ELISAs or Competitive Immunoassays. In the latter case a labeled competitor antigen is used instead of a labeled antibody. The antigen is similar in structure to the analyte and also bonds to the antibody. This leads to competition between the analyte and the competitor for a binding space on the antibody.

We use different dyes and highly-active horseradish peroxidase for detection. We will be pleased to develop immunoassays for you, whether sandwich, indirect or competitive Assays.

At the premises of our sister company Steffens-Biotec, Ebringen (QMS: ISO 13485) we offer manufacturing in accordance with European IVD guidelines for CE labelled test kits and kit compounds.

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About Us

Company details
The BioTeZ Berlin-Buch GmbH is a Biotechnology company founded in 1992. BioTeZ is partner of research institutions, the pharmaceutical industry and laboratory diagnostics.

Our sister company Steffens-Biotec, Ebringen (ISO 13485) is specialised in manufacturing CE in-vitro diagnostics.

We are happy to talk about your ideas and needs in the fields of:

Target enrichment with Immunoaffinity chromatography
Monitoring Drug Efficiency with Antibodies as Drugs (TDM)
Autoimmune & Diagnostic ELISA (CE/ IVD)
ELISA & LFA Development
Surfaces functionalization with Poly-Streptavidin and TAPAS Systems (Biotin free)
Measurement of Protease Activity
Oligonucleotides and Aptamers

Company data
Sales volume

1-9 Mio US $
Export content

> 75%
Number of employees

20-49
Foundation

1992
Area of business

Laboratory Equipment
Diagnostics

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