Medical Products Supplies Companies

111 Pencader Drive, 19702 Newark, DE
USA
Telephone +1 302 456-6789
Fax +1 302 456-6770
sales@sdix.com
http://www.sdix.com

Product Categories

Product categories

03 Diagnostic Tests
03.01 Clinical chemistry
03.01.03 Urinalysis equipment and systems

Urinalysis equipment and systems

03 Diagnostic Tests
03.01 Clinical chemistry
03.01.05 Other equipment for clinical chemistry

Other equipment for clinical chemistry

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.02 Diagnostic rapid tests

Diagnostic rapid tests

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.03 Diagnostic tests for cancer

Diagnostic tests for cancer

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.04 Other equipment for immunochemistry and immunology

Other equipment for immunochemistry and immunology

03 Diagnostic Tests
03.05 Infectious immunology testing
03.05.02 Microbiological diagnosis, virology, equipment and systems for

Microbiological diagnosis, virology, equipment and systems for

*ALK
AFP
AMACR
Beta-Catenin
CK20 / Keratin-20

Our products

Product category: Microbiological diagnosis, virology, equipment and systems for
*ALK
The ALK gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain and hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumors including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[Provided by RefSeq, Jan 2011].

Alternative names: Anaplastic lymphoma kinase also known as ALK tyrosine kinase receptor or CD246

Product category: Microbiological diagnosis, virology, equipment and systems for
AFP
Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Product category: Microbiological diagnosis, virology, equipment and systems for
AMACR
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for the degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor-related protein 3) gene. [provided by RefSeq, Mar 2011].

Alternative names: AMACRD; CBAS4; RACE; RM

Product category: Microbiological diagnosis, virology, equipment and systems for
Beta-Catenin
Beta-Catenin is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-Catenin also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this protein are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.

Alternative names: CTNNB1

Product category: Microbiological diagnosis, virology, equipment and systems for
CK20 / Keratin-20
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].

Alternative names: CD20; CK-20; CK20; K20; KRT21

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About Us

Company details
SDIX is a wholly owned subsidiary of OriGene Technologies, specializing in high quality, large-scale GMP antibody production in the U.S.; Delaware and Maine.

For over 25 years, SDIX has been a leading immuno-solutions company, developing results-oriented and innovative antibody-based solutions that enable customers, world-wide, to meet high performance diagnostic and commercialization objectives. All sites are ISO 13485:2016 certified and the manufacturing site in Delaware is FDA and MHRA registered for the manufacture and export of class I IHC reagents and kits.

For IHC applications, over 40 CE-marked IVD reagents are manufactured and sold in the EU and US. Other products include critical reagents such as antibodies to Troponin I, Strep A, CRP, Apo A1, ApoB, Micro-albumin and Calibrators. SDIX also provides both polyclonal and monoclonal antibody development and production services, including long term supply of monoclonal antibodies for IVD and drug development applications as well as polyclonal antibody production in goat, rabbit and other species.

In the life science market, SDIX’s technology and capabilities are being used to help discover disease mechanisms, facilitate development of new drugs, and provide antibodies and assays utilized in the diagnosis of disease.

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