Medical Products Supplies Companies

Via Trento 124, 38061 Ala
Italy
Telephone +39 0464 357951
Fax +39 0464 357964
info@biomat.it
http://www.biomat.it

Product Categories

Product categories

02 Laboratory Technology
02.13 Microplate, microtiter plates

Microplate, microtiter plates

03 Diagnostic Tests
03.02 Immunochemistry testing, immunology testing
03.02.01 Immuno assay testing

Immuno assay testing

03 Diagnostic Tests
03.06 Genetic testing, molecular diagnostics
03.06.03 Polymerase chain reaction (PCR)

Polymerase chain reaction (PCR)
Our products

Product category: Microplate, microtiter plates
96 WELL PLATES
Biomat ‘s full range of 96 well plates for immunoassay includes solid plates, 8 well strip plates format (assembled on 12 x 8 well-holding frame) and in 8-well breakable strip plates format (on single well-holding frame), allowing the maximum flexibility for the user.

The 96-well plates are made in Transparent, White and Black Polystyrene and can be used for ELISA, Luminescence and Fluorescence assays.

Their design offers the best performances thanks to the following features:

manufactured in pure polystyrene with low fluorescence
the optical quality, important to reduce the background signal, is pursued through the mould design
the radius edged inner bottom of the wells improves the efficiency of washings
the external lid warrants vertical alignment when using single wells
a rim protects the external face of the bottom from scratches
the plates comply with SBS standards and the design assures a good performance in an automatic processing plant

Every 96 well plate is offered with more than 20 surfaces’ modifications: these allow maximum flexibility for the user upon its needs.

Product category: Microplate, microtiter plates
HIGH BINDING 96-WELL PLATES
The High Binding Capacity 96-Well Plate are offered in 3 different formats:

8 well breakable strips
8 well strip
Solid

Clear, white and black microplates are manufactured in pure polystyrene with low fluorescence and can be used for ELISA, Luminescence and Fluorescence assays. White and black plates have minimal light scatter and prevent well-to-well crosstalk.

The strips’ plates are designed to be easily breakable by the user and repositioned in the frame; the radius edged inner bottom of the wells improves the efficiency of washing.

The High Binding Capacity 96 Well Plate comply with SBS standards and the design assures a good performance in automatic processing plant.

Recommended working volume of 75 to 300 μl
Packaging: 25 plates in a transparent bag
96-Well Plates

We offer High Binding 96 Well Plates in the following formats:

Product category: Polymerase chain reaction (PCR)
PCR PRODUCTS
The polymerase chain reaction (PCR) has become one of the most widely used techniques in molecular biology. It is used in applications from basic research to high-throughput screening.

PCR plates and strip tubes are made in polypropylene (PP) and while PP features of temperature resistance and low binding capacity fit with the needs of PCR protocol, some recent techniques as e.g. NGS, require binding properties.

While polystyrene (PS) polymer is easily subject to binding capacity improvement and is able to bind a wide range of molecules, the polypropylene (PP) is an inert polymer.

Thanks to a proprietary method for improving the binding capacity of polypropylene, now PCR 8 tubes strips or PCR plates are offered with coated molecules: Protein A, Protein A/G, Protein G, Streptavidin, Streptavidin HB.

Product category: Polymerase chain reaction (PCR)
PCR Plates
Biomat PCR plates are made in clear polypropylene coated with different molecules for your needs. Their thin walls optimize the heat transfer from the block to the reaction solution. while the rim of the wells is designed to protect against cross-contamination, allowing a reliable seal with the sealing mats tailored to the plates.

We offer three different types of plates suitable for Real-Time PCR:
– 96-well non-skirted PCR plates, suitable for most commercially available thermal cyclers.
– 96-well semi-skirted PCR plates, easily be labeled or tagged with a barcode.
– 96-well skirted PCR plates: especially rigid, and optimal suited for use with automatic pipetting systems and for being transported.

All Biomat’s PCR plates are pre-blocked with standard proteic blocking (ELISA Blocking).

Thanks to a proprietary method for improving the binding capacity of polypropylene, Biomat offers coated PCR plates with these molecules:

Streptavidin
HB streptavidin
Protein A
Protein G
Protein A/G

or with different molecules upon request.

Product category: Polymerase chain reaction (PCR)
PCR 8 Strip Tubes
Protein A PCR 8 Strip Tubes are 8 connected 0.2 ml tubes made in clear polypropylene; they have thin walls that optimize the heat transfer from the block to the reaction solution.
The Protein A PCR 8 Strip Tubes are available with or without flat caps; they are easy to open and close without tools and are compatible with most popular thermal cycler blocks.

Each PCR strip tubes has each numerically identified tube (from 1 to 8) for easy recognition and the strips have a holding strap at one end.
PCR 8 strip tubes are pre blocked with standard proteic blocking (ELISA Blocking)
Recommended working volume of 50 to 100 μl

PACKAGING

10 coated PCR 8 strips tubes in a single barrier bag with desiccant.
Every single unit contains 50 PCR 8 strips tubes

BIOMAT OFFERS PCR 8 STRIPTUBES WITH THE FOLLOWING SURFACES:

Protein A
Protein A/G
Protein G
Streptavidin
Streptavidin HB

Product category: Immuno assay testing, Microplate, microtiter plates
Coating services and surface modification
Coating services and surface modification offer a great solution when organizations or labs need to obtain specific properties from their devices.

Biomat’s 25+ years of experience in the coating services and surface modification, which includes the cooperation with primary scientific institutions, enables us to offer a top-quality and reliable coating and surface modification service to companies, laboratories, researchers and institutions operating in the diagnostic and pharmaceutical fields.

By exploiting the current cutting-edge technologies for biotechnology Biomat offers coating services and surface modification for the following applications:

Immobilization of oligonucleotides on biocoated microplates
Poly-L-lysine coated microplate for Purified DNA binding
Streptavidin coating onto proprietary micro-fluidic devices made of different polymers
Activation and coating of POC devices
Cell binding on PE membrane

We know that surface modification and coating services in the development of new drugs or assays related to DNA areas, require very specific knowledge and expertise.

Moreover, knowledge and protocol transfer between the laboratory and the industrial application requires, besides the expertise, high equipment investments (suited only for small pre-series applications) and long time to put into place.

Outsourcing these phases has proven the best solution for most organizations That is why Biomat offers to its customers:

EXPERTISE
RELIABILITY
PRODUCTION CAPACITY

Biomat understands that the availability of new polymers, with improved physical and optical properties, and the use of new moulding and machining techniques, for more precise and micro-finished devices, creates challenges whenever the user needs to obtain particular properties.
As an example, transferring such common property as the protein binding capacity from polystyrene (High Binding treated) to a different polymer with better physical properties (e.g. transparency), demands a lot of testing.
An advanced knowledge of the properties of each material in combination with the specific requirements of each application is needed.

The know-how and expertise of companies in the field must include:

The ability to apply the same technology to different applications, materials, etc.
The development of testing methods to evaluate the status of the surface: (ie. Is the coating molecule active and are its binding sites available?)

Biomat, as a partner in the development of coated or modified surfaces, guarantees a product with demonstrated and proven properties, so that the client can rely on guaranteed support for its product or technology.

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Coating Services

Product category: Microplate, microtiter plates, Immuno assay testing
Surface Treatment
Biomat over 25 years experience in the surface treatment field has built a world-renowned reputation as a professional and reliable partner.

We offer surface modifications on Polystyrene, Polypropylene, POC, COC products:

microplates,
tubes,
slides,
microchannel devices

Biomat applies a wide range of techniques for surface modifications:

Plasma (glow discharge)
Chemical modification
Biological coating

Every specific surface treatment is studied and developed by our scientists taking into consideration the characteristics in order to obtain the surface properties needed for each specific application.

Biomat offers both:

Surface treatment service
Technology transfer

PLASMA TREATMENTS
Plasma treatments are particularly suitable to be employed in the biomedical field thanks to their characteristics.

BIOCHIPS
DIAGNOSTIC DEVICES
MEMBRANES AND FILTERS

Product category: Microplate, microtiter plates, Immuno assay testing, Polymerase chain reaction (PCR)
Plasma Treatment
PROBLEM
The field of biomedical applications needs polymers that, besides satisfying the physical requirements of their application, offer biocompatibility, this means that they need to react adequately in combination to the biological environment in which they are employed.

SOLUTION
Given that biocompatibility involves the interaction between the device and the biological environment, surface modification techniques offer a great solution to this problem with the benefit of avoiding costly changes of materials.

Among surface modification techniques that Biomat has tested over the years, cold plasma has proven to be the best solution thanks to its characteristics:

FAST RESPONSE
FLEXIBILITY
ECONOMIC

Biomat’s plasma treatments are suitable for:

preparing hydrophilic or hydrophobic surfaces
suitable for biomedical and industrial applications
improve the adhesion of inks, paints and glues
surface cleaning / etching

Biomat has offered plasma treatment on a wide range of articles for its client:

Cuvettes
Filters
Membranes
Biochips

The treated products have proven an improvement in their performance related to the biological activity thanks to the plasma treatment.

Biomat Plasma Offer
Biomat 25+ years of industry knowledge and research has allowed to develop a cutting edge in-house facility and process. Biomat studies, develops and applies surface treatments to customers items cooperating with the customer in order to find the best solution in term of technical and economical features.

Plasma Process
Biomat’s plasma equipment consists in a vacuum chamber with one or more gas inlet (equipped with proper dosing systems), two electrodes connected to a RF (or different frequency) generator are located within the chamber in order to supply to the gas that flows between them the energy that excite its molecules generating the plasma.

Biomat continuous research in the sector has allowed us to develop the following cutting-edge process for plasma treatment:

client’s requirements analysis (applications, properties and costs)
item’s material assessment
articles to be treated are placed within the chamber
a fixed degree of vacuum is reached
a fixed amount of the chosen gas(es) is made to flow through the chamber and excited by the electrical discharge creating the PLASMA
the reactive species of plasma react with the surface of the device modifying its properties

The process works in a limited time (from seconds to minutes) at practically room temperature affecting only the surface of the parts that are treated nothing else.

Plasma process has proven perfect for many surface modifications thanks to the following features:

Limited action to the thin surface layer without affecting the bulk properties of the material
Short exposition time (few minutes)
Low temperature: the process temperature is near to the room temperature, which avoids unwanted effects on the polymers
Flexibility: it works on a wide range of materials and applications (from degreasing of a metallic surface to deposition of a new polymeric layer)
Uniformity and reproducibility: in comparison with other surface modification techniques, such as chemical or corona, the plasma process, being run under strictly controlled conditions (vacuum) and parameters, warrants a constancy of results
Environment-friendly the dry nature of the process means no pollution on the treated parts and no chemical effluents, after the treatment, the parts need no additional process
Cost-effective: the above-listed features mean low operating cost

Plasma applications
Depending upon the type of gas or vapor that is employed in the plasma process it is possible to obtain different effects:

Plasma cleaning: plasma removes every organic contaminant from the surface leaving a surface cleaned on a molecular scale
Surface activation: employs a reactive gas (e.g. O2, N2) which creates different functional groups modifying the hydrophilicity and the biochemical reactivity of the polymer’s surface plasma-induced grafting employs inert gases (e.g. Ar, He) which remove some atomic species from the basic polymer generating reactive and cross-linked surfaces
Plasma deposition: some gases (e.g. Methane) can be plasma polymerised, coating the device’s surface with a thin layer of a different polymer

One of the most used applications of the COLD PLASMA technology is the modification of the wettability of the polymers. Polymers usually show an unwettable surface (contact angle > 90°).

This property means that, whenever a good adhesion to the surface is required, a poor response is encountered and therefore the surface needs to be treated to reach acceptable adhesion levels. Examples of application where a good wettability is important are, for example:

adhesion of biological molecules binding proteins for immunoassays application – Tissue Culture surfaces
gluing
inking
painting

Since every type of polymer shows different properties, Biomat studies the treatment and application for each specific material, taking into consideration the following features:

the raw material
the shape of the part
the application

Once assessed the intrinsic feature and properties of the item treated our scientist adjust the following parameters to reach the required result:

TYPE OF GAS(ES)
TIME
POWER

Once the process is completed the products will be analyzed by our lab for:

effectiveness of the treatment
uniformity
durability of its effects during storage

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About Us

Company details
Biomat’s mission is to support IVD manufacturers and researchers by offering high quality and reliability surface-modified products and surface modification services.

We offer high-quality:

MICROPLATES: 96 well plates, glass bottom plates, HTS, Tissue Culture plates
PCR PRODUCTS: PCR strip tubes and PCR tubes caps
OTHER PRODUCTS: 12 x 75 tubes, special products, reagents

for immunoassays, research and other applications in the diagnostic field.

We study and develop innovative products with specific properties for our customers’ needs thanks to our expertise in moulded products development and surface modification. To do so we employ the most advanced techniques: from cold plasma to different protein coatings.

HISTORY
Biomat was established in 1992 as an engineering company dedicated to the development of special plastic products (microplates, PCR products, and other products) for diagnostic and medical applications.

The growing need of surfaces capable of binding biological molecules oriented us to focus on the surface modifications employing different technologies: from plasma to bio-coating and our team developed a wide experience in these fields enabling us to offer customized solutions.

In 1995 we started the production of our own microplates for immunoassays with modified surfaces. From the original Medium and High Binding capacity 96 well plates for ELISA, LIA and FIA, we extended our production to different formats and developed several types of surfaces.

Our knowledge of surface modifications, employing different technologies and working on different products, enables us to serve IVD manufacturers and researches operating in the different fields that need surface modified articles: from microplates to Petri dishes, to a wide range of custom made articles.

IVD manufacturers represent Biomat’s main customers, but new areas such as molecular diagnostic and genomics need very specific surface properties applied onto different platforms from PS microplates to PP PCR products.

The fields of applications of Biomat’s products are:

ELISA – LIA – FIA
MOLECULAR BIOLOGY
HTS
TISSUE CULTURE

At the same time, the new platforms such as biochips, microarrays or multiple immunoassays, extend the application of the coated/modified surfaces to different applications such as:

DNA methylation
Binding of Oligos
Detection of Exosomes

Throughout the years, Biomat has constantly invested in cutting-edge innovation of its products and services in order to offer the most advanced technologies for new immunoassays and research applications.

For over 20 years Biomat has been trusted worldwide for:

the quality and reliability of its products,
its excellent focus on customers needs
the cutting-edge investment in research
its great and prompt customer service

STRATEGY
The biomedical field needs multi-disciplinary expertise, that is the reason why Biomat has built a network of reliable companies capable of supplying top services related to its activity (e.g. surface analysis).

Our experience and skills include many techniques of surface modification: plasma, Gamma irradiation, chemical, biological coating, which are exploited in order to offer the best technology for each application.

Biomat’s strategy is based on a flexible structure and to the capacity to adapt it to the technological development and to the expansion of the markets.

This is pursued through:

reliable technical installations with a high degree of automation and easy scalability
focusing on research in order to keep the pace with the technological development

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Company data
Sales volume

1-9 Mio US $
Export content

> 75%
Area of business

Diagnostics

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